Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis
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- 作者：Roberta Bonafedea ; Ilaria Scambia ; Daniele Peronib ; Valentina Potrichb ; Federico Boschic ; Donatella Benatia ; Bruno Bonettia ; Raffaella Mariottia ; raffaella.mariotti@univr.it" class="auth_mail" title="E-mail the corresponding author ; raffaella.mariotti1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesenchymal stem cell ; Extracellular vesicles ; Paracrine effect ; ALS ; Motoneuron disease ; Motoneuron-like NSC-34
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：340
- 期：1
- 页码：150-158
- 全文大小：8403 K
文摘
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Hydrogen peroxide was used to induce apoptosis in in vitro model of ALS.
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NSC-34 cells expressing different ALS mutations were used as in vitro model.
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Exosomes isolated from adipose stem cells (ASCs) were used as non-cell-based therapy.
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Exosomes protect motoneuron-like NSC-34 cells from oxidative damage.
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ASCs-exosomes were able to rescue transfected NSC-34 cells from apoptosis.