Mesenchymal stromal/stem cells in drug therapy: New perspective

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• 作者：Lauren S. Sherman¹ ; ² ; Maran Shaker¹ ; Veronica Mariotti² ; Pranela Rameshwar¹ ; ² ; ^{rameshwa@njms.rutgers.edu}
• 刊名：Cytotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 页码：19-27
• 全文大小：527 K
• 卷排序：19

文摘

Mesenchymal stromal/stem cells (MSC) have emerged as a class of cells suitable for cellular delivery of nanoparticles, drugs and micro-RNA cargo for targeted treatments such as tumor and other protective mechanisms. The special properties of MSC underscore the current use for various clinical applications. Examples of applications include but are not limited to regenerative medicine, immune disorders and anti-cancer therapies. In recent years, there has been intense research in modifying MSC to achieve targeted and efficient clinical outcomes. This review discusses effects of MSC in an inflammatory microenvironment and then explains how these properties could be important to the overall application of MSC in cell therapy. The article also advises caution in the application of these cells because of their role in tumorigenesis. The review stresses the use of MSC as vehicles for drug delivery and discusses the accompanying challenges, based on the influence of the microenvironment on MSC.