A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation
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- 作者：Paul Boona ; Paul.Boon@UGent.be" class="auth_mail" title="E-mail the corresponding author ; Kristl Vonckb ; kristl.vonck@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Kenou van Rijckevorselc ; kenou.vanrijckevorsel@uclouvain.be" class="auth_mail" title="E-mail the corresponding author ; Riem El Tahryc ; riem.eltahry@uclouvain.be" class="auth_mail" title="E-mail the corresponding author ; Christian E. Elgerd ; christian.elger@ukb.uni-bonn.de" class="auth_mail" title="E-mail the corresponding author ; Nandini Mullattie ; nandini.mullatti@nhs.ne" class="auth_mail" title="E-mail the corresponding author ; Andreas Schulze-Bonhagef ; andreas.schulze-bonhage@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Louis Wagnerg ; WagnerL@kempenhaeghe.nl" class="auth_mail" title="E-mail the corresponding author ; Beate Diehlh ; beate.diehl@uclh.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Hajo Hameri ; hajo.hamer@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author ; Markus Reuberj ; Markus.Reuber@sth.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Hrisimir Kostovk ; hrisimik@ous-hf.no" class="auth_mail" title="E-mail the corresponding author ; Benjamin Legrosl ; blegros@ulb.ac.be" class="auth_mail" title="E-mail the corresponding author ; Soheyl Noachtarm ; soheyl.noachtar@med.uni-muenchen.de" class="auth_mail" title="E-mail the corresponding author ; Yvonne G. Webern ; yvonne.Weber@uni-tuebingen.de" class="auth_mail" title="E-mail the corresponding author ; Volker A. Coenenf ; volker.coenen@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; Herbert Rooijakkerso ; herbert.rooijakkers@uclouvain.be" class="auth_mail" title="E-mail the corresponding author ; Olaf E.M.G. Schijnsg ; p ; o.schijns@mumc.nl" class="auth_mail" title="E-mail the corresponding author ; Richard Selwaye ; richard.selway@nhs.net" class="auth_mail" title="E-mail the corresponding author ; Dirk Van Roostb ; dirk.vanroost@ugent.be" class="auth_mail" title="E-mail the corresponding author ; Katherine S. Egglestonq ; katherine.eggleston@cyberonics.com" class="auth_mail" title="E-mail the corresponding author ; Wim Van Grunderbeekr ; wim.vangrunderbeek@cyberonics.com" class="auth_mail" title="E-mail the corresponding author ; Amara K. Jayewardeneq ; amara.jayewardene@cyberonics.com" class="auth_mail" title="E-mail the corresponding author ; Ryan M. McGuireq ; ryan.mcguire@cyberonics.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vagus nerve stimulation ; Ictal tachycardia ; Cardiac based seizure detection ; Refractory epilepsy ; Quality of life
- 刊名：Seizure
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：32
- 期：Complete
- 页码：52-61
- 全文大小：4018 K
文摘
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First clinical trial in epilepsy with combined open and closed-loop VNS.
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Cardiac-based seizure detection had greater than 80% sensitivity.
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Seizure severity significantly improved after 3–5 days of closed-loop stimulation.
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Long-term combined open and closed-loop VNS improved quality of life.