Role of central opioid on the antinociceptive effect of sulfated polysaccharide from the red seaweed Solieria filiformis in induced temporomandibular joint pain
F II has antinociceptive and anti-inflammatory effect in the TMJ. F II inhibits the release of inflammatory cytokines IL-1β and TNF-α. F II increases the β-endorphin release in the subnucleus caudalis. The antinociceptive effect of F II depends on the opioid receptors mu, delta e kappa.