Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A1 receptor-dopamine D1 receptor interaction and PKA-dependent mechanisms
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- 作者：JeanMarie Acevedo ; Alexandra Santana-Almansa ; Nikol Matos-Vergara ; Luis René ; Marrero-Cordero ; Ernesto Cabezas-Bou ; Manuel Dí ; az-Rí ; os ; manuel.diaz6@upr.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Caffeine ; Locomotion ; Spinal cord ; Adenosine ; Mouse ; Dopamine
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：490-505
- 全文大小：3604 K
文摘
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We used the neonatal mouse spinal cord to study the effects of caffeine.
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We examined changes in fictive locomotor activity focusing on bursting activity.
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Caffeine stimulated locomotion through blockade of A1 receptors.
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The effects of caffeine were found to depend on the activation of D1 receptors.
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Caffeine stimulation of locomotion is dependent on PKA intracellular signaling.