Alternative strategies for Clostridium difficile infection

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• 作者：Martijn P. Bauer ; Jaap T. van Dissel
• 关键词：Clostridium difficile ; Probiotics ; Polymers ; Immunotherapy ; Anti-Clostridium difficile whey concentrate ; Faecotherapy
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：33
• 期：Supplement 1
• 页码：S51-S56
• 全文大小：136 K

文摘

Although antibiotics are generally effective in achieving symptomatic recovery from Clostridium difficile infection, the disease frequently relapses, partly because antibiotics not only kill C. difficile, but also disrupt colonisation resistance of the gut microflora. Non-antibiotic strategies for the prevention and treatment of the infection include probiotics, deliberate colonisation by non-toxigenic C. difficile strains, toxin-binding agents, active immunisation, passive immunotherapy with intravenous immunoglobulin, monoclonal antibodies or bovine anti-C. difficile whey concentrate, and faecal transplantation. None of these alternative therapies has proven benefit in therapy or prevention, and prospective randomised trials are urgently needed.