Acantholytic squamous cell carcinoma arising in actinic keratoacanthoma: Two cases with E-cadherin expression supporting a potentially different prognosis

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• 作者：Vicente Sabater Marco^a ; ^{Vicente.sabater@uv.es" class="auth_mail" title="E-mail the corresponding author} ; Ana Garcí ; a Rabasco^b ; Miguel Martorell Cebollada^a ; Rafael Botella Estrada^c
• 关键词：Keratoacanthoma ; Acantholytic squamous cell carcinoma ; Malignant transformation ; E-cadherin ; p63 ; Prognosis
• 刊名：Revista Española de Patología
• 出版年：2016
• 出版时间：January-March 2016
• 年：2016
• 卷：49
• 期：1
• 页码：23-26
• 全文大小：1952 K

文摘

Among crateriform squamous proliferation, keratoacanthoma is considered as a squamous cell carcinoma or as a non-malignant, self-healing lesion that frequently becomes malignant. To date, published cases of neoplasms originating from keratoacanthoma are always conventional squamous cell carcinomas. Acantholytic squamous cell carcinoma arising in keratoacanthomas has not been previously reported. We present two crater-shaped nodular lesions on the face of elderly patients with clinical and histopathological features of keratoacanthoma with transformation areas to acantholytic squamous cell carcinoma. In the immunohistochemical study, Ki-67 and p63 immunostaining supports the diagnosis of acantholytic squamous cell carcinoma ex-keratoacanthoma. We suggest that E-cadherin expression and vimentin negativity could probably be related with less aggressive behaviour and a better prognosis.