- 作者：Ranjiv Mathews ; Myra Carpenter ; Russell Chesney ; Alej ; ro Hoberman ; Ron Keren ; Tej Mattoo ; Marva Moxey-Mims ; Lee Nyberg ; Saul Greenfield
- 关键词：Urinary tract infections ; Vesicoureteral reflux
- 刊名：Journal of Pediatric Urology
- 出版年：2009
- 出版时间：October 2009
- 年：2009
- 卷：5
- 期：5
- 页码：336-341
- 全文大小：174 K
Methods
Review of the recent literature has demonstrated a growing concern that antibiotic prophylaxis may not lead to prevention of UTIs. Additionally, data indicate that renal scarring may not be preventable with antibiotic prophylaxis or even surgical correction of VUR. An overview of all of the current controversies is presented in this paper.
Results
Does antibiotic prophylaxis lead to reduction in UTIs in children with VUR? To address this question, the National Institutes of Health have developed a randomized placebo-controlled study of children with VUR (the RIVUR Study), identified following the development of a UTI.
Conclusions
There are far reaching consequences of the results of the RIVUR Study. If antibiotic prophylaxis does not prevent UTI in children with VUR, or lead to reduction in renal scarring, does identification of VUR provide any benefits? Perhaps appropriate treatment of UTI may be all that is necessary for preserving renal function. Final answers will have to wait until the completion of this study.