A novel 5-way translocation t(9;11;13;19;22) in a case of chronic-phase chronic myeloid leukemia

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• 作者：Shantashri Vaidya ; Dolly Joshi ; Kanjaksha Ghosh ; Prantar Chakrabarti ; Babu Rao Vundinti
• 关键词：BCR/ABL gene ; Chronic myeloid leukemia ; Chronic phase ; 5-Way translocation
• 刊名：Human Pathology
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：44
• 期：10
• 页码：2365-2369
• 全文大小：1036 K

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Summary

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder that occurs because of t(9;22)(q34;q11) translocations. Complex translocations have been reported in CML. We report a novel 5-way translocation 46,XY,t(9;11;13;19;22)(9q34.12;11p11.12;13q21.31;19q13.12;22q11.21) using GTG banding, fluorescence in situ hybridization, and spectral karyotyping in a case of chronic-phase CML. Molecular analysis revealed the presence of 2 types of transcripts (b3a2, b2a2). The patient was responding to the imatinib treatment. However, the patient needs to be carefully monitored at various intervals.