Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing

详细信息    查看全文

• 作者：Leonard B. Bacharier ; Brenda R. Phillips ; Robert S. Zeiger ; Stanley J. Szefler ; Fern ; o D. Martinez ; Robert F. Lemanske Jr. ; Christine A. Sorkness ; Gordon R. Bloomberg ; Wayne J. Morgan ; Ian M. Paul ; Theresa Guilbert ; Marzena Krawiec ; Ronina Covar ; Gary Larsen ; Michael Mellon ; Mark H. Moss ; Vernon M.
• 关键词：Wheezing ; preschool children ; montelukast ; budesonide
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2008
• 出版时间：December 2008
• 年：2008
• 卷：122
• 期：6
• 页码：1127-1135.e8
• 全文大小：537 K

文摘

Background

Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity.

Objectives

We sought to examine the effectiveness of episodic use of an inhaled corticosteroid and a leukotriene receptor antagonist in preschoolers with intermittent wheezing.

Methods

In a randomized, double-blind, placebo-controlled 12-month trial, 238 children aged 12 to 59 months with moderate-to-severe intermittent wheezing received 7 days of either budesonide inhalation suspension (1 mg twice daily), montelukast (4 mg daily), or placebo in addition to albuterol with each identified respiratory tract illness (RTI). Proportion of episode-free days (EFDs) during the 12-month trial was the primary outcome.

Results

The 3 treatment groups did not differ in proportions of EFDs, with adjusted mean EFDs of 76 % (95 % CI, 70 % to 81 % ) for budesonide, 73 % (95 % CI, 66 % to 79 % ) for montelukast, and 74 % (95 % CI, 65 % to 81 % ) for conventional therapy (P = .66). The 3 groups did not differ in oral corticosteroid use, health care use, quality of life, or linear growth. However, during RTIs, budesonide and montelukast therapy led to modest reductions in trouble breathing (38 % [P = .003] and 37 % [P = .003], respectively) and interference with activity scores (32 % [P = .01] and 40 % [P = .001], respectively) that were most evident in those with positive asthma predictive indices.

Conclusions

In preschool children with moderate-to-severe intermittent wheezing, episodic use of either budesonide or montelukast early in RTIs, when added to albuterol, did not increase the proportion of EFDs or decrease oral corticosteroid use over a 12-month period. However, indicators of severity of acute illnesses were reduced, particularly in children with positive asthma predictive indices.