Differences in sequential posttreatment salivary IL-6 levels between patients with and patients without locoregional recurrences of oral squamous cell carcinoma: Part III of a cohort study

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• 作者：Jun Sato ; DDS ; PhD^a ; ^{jun-s@den.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Manabu Ohuchi ; DDS ; PhD^b ; Mayumi Wada ; DDS ; PhD^b ; Noritaka Ohga ; DDS ; PhD^c ; Takuya Asaka ; DDS ; PhD^c ; Kazuhito Yoshikawa ; DDS ; PhD^c ; Masaaki Miyakoshi ; DDS ; PhD^c ; Hironobu Hata ; DDS ; PhD^c ; Akira Satoh ; DDS ; PhD^a ; Yoshimasa Kitagawa ; DDS ; PhD^d
• 刊名：Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：120
• 期：6
• 页码：751-760.e2
• 全文大小：1595 K

文摘

Sequential postoperative salivary interleukin-6 (IL-6) concentrations were examined in patients with oral squamous cell carcinoma (OSCC) who had early or late locoregional recurrences or those who did not.

Study Design

Twenty-seven consecutive patients with OSCC were originally included in the study. All patients underwent radical surgery. Four saliva samples were collected before (periods I and II) and after (periods III and IV) surgery, and IL-6 concentrations were measured.

Results

Although postoperative (period III: at the time of discharge) salivary IL-6 level was significantly higher in patients with early locoregional recurrence (P = .02) than in those without, no such relationships were observed for preoperative IL-6 concentrations (periods I and II). Postoperative (period IV: 24 months after surgery) IL-6 level was significantly higher in patients with late locoregional recurrence (P = .03) than in those without, but no such relationships were observed for IL-6 concentrations in periods I, II, and III.

Conclusions

Sequential postoperative salivary IL-6 concentration may be a useful marker for diagnosis of early and late locoregional recurrence in OSCC.