PPARα gene expression is up-regulated by LXR and PXR activators in the small intestine

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• 作者：Jun Inoue ; Shin-ichi Satoh ; Mariko Kita ; Mayuko Nakahara ; Satoshi Hachimura ; Masaaki Miyata ; Tomoko Nishimaki-Mogami ; Ryuichiro Sato
• 关键词：GW3965 ; LXR ; PCN ; PPAR ; //www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0""> ; PXR ; T0901317 ; Transcriptional regulation ; Lipid metabolism
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2008
• 出版时间：11 July 2008
• 年：2008
• 卷：371
• 期：4
• 页码：675-678
• 全文大小：197 K

文摘

LXR, PXR, and PPAR are members of a nuclear receptor family which regulate the expression of genes involved in lipid metabolism. Here, we show the administration of T0901317 stimulates PPAR gene expression in the small intestine but not in the liver of both normal and FXR-null mice. The administration of LXR specific ligand GW3965, or PXR specific ligand PCN has the same effect, indicating that ligand-dependent activation of LXR and PXR, but not FXR, is responsible for the increased gene expression of PPAR in the mouse small intestine.