Recurrent exacerbations affect FEV₁ decline in adult patients with cystic fibrosis

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• 作者：Anna Amadori ; Andrea Antonelli ; Ilaria Balteri ; Anja Schreiber ; Massimiliano Bugiani ; Virginia De Rose
• 关键词：Cystic fibrosis in adults ; Exacerbations ; FEV₁ decline
• 刊名：Respiratory Medicine
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：103
• 期：3
• 页码：407-413
• 全文大小：320 K

文摘

class=""h3"">Summary

Obstructive lung disease is the major cause of morbidity and mortality in cystic fibrosis (CF). To identify risk factors contributing to FEV₁ decline in CF patients, we carried out a retrospective analysis of clinical and pulmonary function data in a population of CF patients followed up for 5 years and studied the correlation between clinical data and FEV₁ decline.

Fifty-one adult CF patients were studied. The FEV₁ decline was related to the following clinical characteristics: CFTR genotype, age, gender, weight, height, age at diagnosis, baseline FEV₁, pancreatic function, presence of airway infection, pancreatic insufficiency and diabetes, number of exacerbations/year and intravenous (i.v.) antibiotic courses/year.

Both the number of exacerbations/year and the number of i.v. antibiotic courses/year were strongly related to the FEV₁ decline. Patients with airway infection or with diabetes had significantly lower FEV₁ values during the study as compared with non-infected patients or patients without diabetes; however, both the presence of airway infection or diabetes did not affect the FEV₁ decline.

These results suggest that the aggressive treatment of disease exacerbations is crucial for delaying lung function decline in CF.