- 作者：Stefano Pretta ; Valentino Remorgida ; Luiza Helena Abbamonte ; Paola Anserini ; Nicola Ragni ; Massimo Del Sette ; Carlo G ; olfo ; Simone Ferrero
- 关键词：Atherosclerosis ; Distensibility coefficient ; Endometriosis ; Intima-media thickness
- 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
- 出版年：2007
- 出版时间：June 2007
- 年：2007
- 卷：132
- 期：2
- 页码：226-231
- 全文大小：132 K
This study aims to determine whether women with endometriosis have greater subclinical atherosclerosis than the general population.
Study design
This case-control study included 66 women with endometriosis and 66 controls matched for age and body mass index. All subjects were ≥35 years old. Exclusion criteria were obesity, diabetes, hypertension, hyperlipidemia, renal or metabolic diseases. Before laparoscopy, all patients underwent a measurement of intima-media thickness (IMT) and distensibility coefficient (DC) on the common carotid artery. In addition, blood samples were taken to determine the levels of lipids, fibrinogen, C-reactive protein, homocysteine, fasting glycemia, antithrombin III, plasminogen, protein C, protein S, and activated protein C resistance.
Results
All the biochemical parameters evaluated had similar levels in the two study groups. IMT was similar in women with endometriosis and in controls both on left (p = 0.330) and right (p = 0.648) carotid artery. Similarly, no significant difference was observed in the DC between women with endometriosis and controls both on left (p = 0.539) and right (p = 0.178) carotid artery. No significant difference was observed in IMT and DC between women with mild and severe endometriosis.
Conclusion
Women with endometriosis do not have more subclinical atherosclerosis than the general population.