Phosphatidylinositol 3-kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts
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- 作者：Ronald W. Matheny Jr.<sup> ; sup><sup>ronald.w.matheny.civ@mail.mil" class="auth_mail" title="E-mail the corresponding authorsup> ; Alyssa V. Geddis ; Mary N. Abdalla<sup>1sup> ; Luis A. Leandry
- 关键词：Phosphatidylinositol 3-kinase (PI3K) ; AMP-Activated protein kinase (AMPK) ; p110α ; Akt ; Myoblast
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：1117-1122
- 全文大小：1031 K
文摘
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Role of PI3K in regulating AMPK phosphorylation in C2C12 myoblasts was studied.
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PI3K p110α inhibition increased AMPK T172 phosphorylation.
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Expression of constitutively-active p110α increased AMPK S485/491 phosphorylation.
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Akt inhibition prevented p110α-induced phosphorylation of AMPK S485/491.
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Stress further increased AMPK T172 phosphorylation in p110α-deficient myoblasts.