- 作者：Andrea Michielan ; Daniela Basso ; Matteo Martinato ; Surajit Pathak ; Antara Banerjee ; Lydia Oliva ; Mario Plebani ; Giacomo Carlo Sturniolo ; Renata D¡¯Inc¨¤
- 关键词：Antibodies ; Crohn's disease ; Relatives
- 刊名：Digestive and Liver Disease
- 出版年：2013
- 出版时间：November, 2013
- 年：2013
- 卷：45
- 期：11
- 页码：894-898
- 全文大小：473 K
Background
Antibodies directed towards bacterial antigens are considered as serological markers of Crohn's disease. Their role in disease pathogenesis is still under investigation.Aim
Assess the serologic response towards microbial antigens in Crohn's disease patients, their unaffected first-degree relatives and healthy controls.
Methods
This retrospective study included 60 Crohn's disease patients, 86 unaffected first-degree relatives and 100 healthy controls. Their sera were tested for anti-chitobioside, anti-laminaribioside, anti-mannobioside, anti-Saccharomyces cerevisiae and anti-outer membrane porin C of Escherichia coli.
Results
The prevalence of anti-chitobioside and anti-laminaribioside was higher in Crohn's disease patients and their first-degree relatives than in healthy controls (51.67 % , 61.63 % and 8 % , respectively, for anti-chitobioside and 76.17 % , 88.37 % and 23.00 % for anti-laminaribioside; p < 0.0001).
The cumulative semiquantitative immune response against all the tested antibodies was higher in unaffected relatives than in healthy controls (p < 0.001).
The quantitative analysis revealed that serum levels of anti-chitobioside, anti-laminaribioside and anti-mannobioside were similar in first-degree relatives and Crohn's disease patients and higher than healthy controls (p < 0.001).
Conclusions
Both qualitative and quantitative analysis revealed that unaffected first-degree relatives have increased antibody response to microbial antigens. This impaired immunological response towards enteric microorganisms may result from a genetic predisposition.