UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
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- 作者：Roland Hjerpe1 ; 2 ; 7 ; John S. Bett1 ; 2 ; 7 ; johnsbett@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author ; Matthew J. Keuss2 ; Alexandra Solovyova3 ; Thomas G. McWilliams2 ; Clare Johnson2 ; Indrajit Sahu4 ; Joby Varghese2 ; Nicola Wood2 ; Melanie Wightman2 ; Georgina Osborne5 ; Gillian P. Bates5 ; Michael H. Glickman4 ; Matthias Trost2 ; Axel Knebel2 ; Francesco Marchesi6 ; Thimo Kurz1 ; 2 ; thimo.kurz@glasgow.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 August 2016
- 年：2016
- 卷：166
- 期：4
- 页码：935-949
- 全文大小：4593 K
文摘
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UBQLN2 clears aggregates independent of autophagy via HSP70 and the proteasome
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A disease mutation in UBQLN2 prevents its binding to HSP70
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Mutant UBQLN2 is defective in clearance of aggregates in vivo
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UBQLN2 knockin mice develop cognitive impairment and brain pathology