Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread
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- 作者：Rebecca L. Lamason1 ; rlamason@berkeley.edu" class="auth_mail" title="E-mail the corresponding author ; Effie Bastounis2 ; 3 ; Natasha M. Kafai1 ; Ricardo Serrano4 ; Juan C. del Á ; lamo4 ; 5 ; Julie A. Theriot2 ; 3 ; Matthew D. Welch1 ; 6 ; welch@berkeley.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：cell-to-cell spread ; host-pathogen interactions ; intercellular tension ; cytoskeleton ; vinculin ; sca4 ; rickettsia parkeri ; listeria monocytogenes ; mechanotransduction ; actin-based motility
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：670-683.e10
- 全文大小：6381 K
文摘
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R. parkeri spread does not rely directly on the force from actin-based motility
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R. parkeri secrete Sca4 to promote protrusion engulfment during spread
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In the donor cell, Sca4 competes with α-catenin for vinculin binding
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Sca4 binding to vinculin specifically reduces intercellular tension forces