Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma
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- 作者：Fakhera Ikrama ; b ; c ; Sandra Ackermanna ; b ; Yvonne Kahlerta ; b ; Ruth Vollanda ; b ; Frederik Roelsa ; b ; Anne Engessera ; b ; Falk Hertwiga ; b ; Hayriye Kocaka ; b ; Barbara Heroa ; b ; Daniel Dreidaxd ; Kai-Oliver Henrichd ; Frank Bertholda ; b ; Peter Nü ; rnbergb ; c ; Frank Westermannd ; Matthias Fischera ; b ; e ; matthias.fischer@uk-koeln.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：TFAP2B ; Neuroblastoma ; Differentiation ; Prognostic marker ; Retinoic acid
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：10
- 期：2
- 页码：344-359
- 全文大小：4160 K
文摘
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Low TFAP2B transcript levels are associated with unfavorable prognostic markers and poor outcome in neuroblastoma.
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TFAP2B may be silenced by promoter methylation in unfavorable neuroblastoma.
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TFAP2B plays a role in neuronal differentiation of neuroblastoma cells.