Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology

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• 作者：Maria S. Robles¹ ; Sean J. Humphrey¹ ; Matthias Mann¹ ; ² ; ^{mmann@biochem.mpg.de}
• 关键词：circadian clock ; mass spectrometry ; rhythmic phosphorylation ; metabolism ; signal transduction
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：118-127
• 全文大小：3377 K
• 卷排序：25

文摘

Large-scale in vivo circadian phosphoproteome More than 25% of sites oscillate daily with large amplitudes in the mouse liver Diverse signaling pathways are temporally orchestrated by phosphorylation Phosphodynamics mediates crosstalk between circadian clocks and metabolism