Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity

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• 作者：Oriane Mauger¹ ; Fré ; dé ; ric Lemoine² ; ³ ; Peter Scheiffele¹ ; ⁴ ; ^{peter.scheiffele@unibas.ch}
• 关键词：splicing ; synapse ; immediate early gene ; plasticity ; intron retention ; NMDA receptor ; Ca2+/calmodulin-dependent protein kinase ; CaMK ; activity-dependent gene expression
• 刊名：Neuron
• 出版年：2016
• 出版时间：21 December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：1266-1278
• 全文大小：2868 K
• 卷排序：92

文摘

PolyA+ transcripts can stably retain select introns and be confined in the nucleus Some of these intron-retaining RNAs rapidly undergo splicing upon neuronal activation Spliced transcripts are exported to the cytosol and loaded onto ribosomes The activity-dependent intron excision process requires NMDAR and CaMK pathways