Identification of CTX-M β-lactamases in Escherichia coli from hospitalized patients and residents of long-term care facilities

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• 作者：Carl Urban ; Noriel Mariano ; Patricia A. Bradford ; Margareta Tuckman ; Sorana Segal-Maurer ; Wehbeh Wehbeh ; Louise Grenner ; Rita Colon-Urban ; Brian Johnston ; James R. Johnson ; James J. Rahal
• 关键词：CTX-M-15 β ; -lactamase ; Escherichia coli infections ; Long-term care facilities ; Antimicrobial resistance
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2010
• 出版时间：April 2010
• 年：2010
• 卷：66
• 期：4
• 页码：402-406
• 全文大小：265 K

文摘

Bacteria harboring CTX-M extended-spectrum β-lactamases (ESBLs) have been identified worldwide, with most reports coming from regions outside North America. We have identified CTX-M enzymes in 31 % of ESBL-positive Escherichia coli isolates from our hospital and more than half (53 % ) of the isolates from associated long-term care facilities. Approximately 3/4 of all CTX-M–bearing isolates were from urine specimens, with a predominance of CTX-M-15. A large proportion of such isolates were nonsusceptible to levofloxacin, trimethoprim/sulfamethoxazole, and all β-lactam antimicrobials with the exception of the carbapenems, requiring carbapenem therapy for acute urinary tract infection or urinary tract-related sepsis. CTX-M β-lactamases have emerged within our location, and detection of bacteria harboring these enzymes in the clinical microbiology laboratory remains problematic because molecular methods are needed for their identification.