RET proto-oncogene mutations affecting codon 790/791: A mild form of multiple endocrine neoplasia type 2A syndrome?
详细信息 查看全文
- 作者：Oliver Gimm ; Barbara E. Niederle ; Theresa Weber ; Maximilian Bockhorn ; Jö ; rg Ukkat ; Michael Brauckhoff ; Phuong Nguyen Thanh ; Andreja Frilling ; Ernst Klar ; Bruno Niederle ; Henning Dralle
- 刊名：Surgery
- 出版年：2002
- 出版时间：December 2002
- 年：2002
- 卷：132
- 期：6
- 页码：952-959
- 全文大小：60 K
文摘
Background. In patients with multiple endocrine neoplasia type 2A syndrome, prophylactic thyroidectomy is generally recommended at the age of 5 to 6 years. Whether this recommendation is justified for exon 13 mutations is unknown. Methods. We analyzed the clinical data from 40 patients harboring RET codon 790/791 mutations (exon 13) who had been treated in 4 specialized centers. Results. Mean age was 35.2 ± 21.6 years (range, 5.1-69.0 years). Thirteen patients were index patients (mean age, 57.7 ± 11.3 years), 27 patients were screening patients (mean age, 24.4 ± 16.5 years). In the index group, pT-category was: T0, N = 2; T1, N = 6; T2, N = 2; T3, N = 1; and T4, N = 2. Lymph node metastases were found in 5 patients and distant metastases in 1 patient. Postoperatively, 69 % of index patients were biochemically cured. In the screening group, pT-category was: T0, N = 19; T1, N = 7; and T2, N = 1. Lymph node metastases were found in 2 patients. Postoperatively, 93 % of screening patients were biochemically cured. The youngest patient with medullary thyroid carcinoma was 13.8 years, the youngest patient with lymph node metastases was 46.4 years. Conclusions. Patients with RET codon 790/791 mutations seemed to have a less aggressive clinical course compared with patients with classic multiple endocrine neoplasia type 2A syndrome. Still, index patients had a lower biochemic cure rate in comparison with screening patients. Timely total thyroidectomy including lymph node dissection is warranted. (Surgery 2002;132:952-9.)