Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer

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• 作者：Wouter van Elmpt ; Marco Das ; Martin H眉llner ; Hoda Sharifi ; Catharina M.L. Zegers ; Bart Reymen ; Philippe Lambin ; Joachim E. Wildberger ; Esther G.C. Troost ; Patrick Veit-Haibach ; Dirk De Ruysscher
• 关键词：Dynamic contrast enhanced (DCE) CT ; Perfusion CT imaging ; FDG-PET ; NSCLC ; Image analysis
• 刊名：Radiotherapy and Oncology
• 出版年：October, 2013
• 年：2013
• 卷：109
• 期：1
• 页码：65-70
• 全文大小：721 K

文摘

Purpose

Dynamic contrast-enhanced CT (DCE-CT) quantifies vasculature properties of tumors, whereas static FDG-PET/CT defines metabolic activity. Both imaging modalities are capable of showing intra-tumor heterogeneity. We investigated differences in vasculature properties within primary non-small cell lung cancer (NSCLC) tumors measured by DCE-CT and metabolic activity from FDG-PET/CT.

Methods

Thirty three NSCLC patients were analyzed prior to treatment. FDG-PET/CT and DCE-CT were co-registered. The tumor was delineated and metabolic activity was segmented on the FDG-PET/CT in two regions: low (<50% maximum SUV) and high (猢?0% maximum SUV) metabolic uptake. Blood flow, blood volume and permeability were calculated using a maximum slope, deconvolution algorithm and a Patlak model. Correlations were assessed between perfusion parameters for the regions of interest.

Results

DCE-CT provided additional information on vasculature and tumor heterogeneity that was not correlated to metabolic tumor activity. There was no significant difference between low and high metabolic active regions for any of the DCE-CT parameters. Furthermore, only moderate correlations between maximum SUV and DCE-CT parameters were observed.

Conclusions

No direct correlation was observed between FDG-uptake and parameters extracted from DCE-CT. DCE-CT may provide complementary information to the characterization of primary NSCLC tumors over FDG-PET/CT imaging.