Particulate matter cytotoxicity in cultured SH-SY5Y cells is modulated by simvastatin: Toxicological assessment for oxidative damage
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- 作者：S.A. Ferraroa ; sebaferraro@gmail.com" class="auth_mail" title="E-mail the corresponding author ; F. Astorta ; J.S. Yakisichb ; D.R. Tasata ; c
- 关键词：SH-SY5Y cells ; Simvastatin ; Cytotoxicity ; ROFA ; Ambient particle ; Air pollution
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：108-114
- 全文大小：1150 K
文摘
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There is a correlation between environmental particulate matter and health effects.
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We studied <em>in vitroem> simvastatin’s potential protective effect on ROFA cytotoxicity.
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ROFA decreased cell viability, increased ROS generation, apoptosis and senescence.
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Pretreatment with simvastatin attenuated the adverse effects observed.
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Simvastatin may provide protection against particulate matter-induced neurotoxicity.