Beta-hydroxy-beta-methylbutyrate (HMB) ameliorates age-related deficits in water maze performance, especially in male rats

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• 作者：Daniel G. Kougias^b ; ^{kougias2@illinois.edu} ; Emily R. Hankosky^a ; ^{hankosky@illinois.edu} ; Joshua M. Gulley^a ; ^b ; ^{jgulley@illinois.edu} ; Janice M. Juraska^a ; ^b ; ^{jjuraska@illinois.edu}
• 关键词：HMB ; Aging ; Water maze ; Sex difference ; Spatial learning ; Spatial memory
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：170
• 期：Complete
• 页码：93-99
• 全文大小：1029 K
• 卷排序：170

文摘

Water maze performance was assessed in middle-aged and aged rats of both sexes. There were age-related deficits in water maze performance in both sexes. Dietary HMB countered age-related deficits in water maze performance in males. Dietary HMB reduced stress-related thigmotactic behavior in females.