Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
详细信息 查看全文
- 作者：Ping Li ; Hamish Allen ; Subhashis Banerjee ; Simon Franklin ; Linda Herzog ; Cynthia Johnston ; Jack McDowell ; Michael Paskind ; Laura Rodman ; Jochen Salfeld ; Elizabeth Towne ; Daniel Tracey ; Scott Wardwell ; Feng-Yi Wei ; Winnie Wong ; Robert Kamen ; Tara Seshadri
- 刊名：Cell
- 出版年：1995
- 出版时间：10 February 1995
- 年：1995
- 卷：80
- 期：3
- 页码：401-411
- 全文大小：1973 K
文摘
IL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. We generated ICE-deficient mice and observed that they are overtly normal but have a major defect in the production of mature IL-1β after stimulation with lipopolysaccharide. IL-1α production is also impaired. ICE-deficient mice are resistant to endotoxic shock. Thymocytes and macrophages from the ICE-deficient animals undergo apoptosis normally. ICE therefore plays a dominant role in the generation of mature IL-1β, a previously unsuspected role in production of IL-1α, but has no autonomous function in apoptosis.