Why Men's Hearts Break: Cardiovascular Effects of Sex Steroids

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• 作者：Brian G. Choi ; MD ; MBA ; Mary Ann McLaughlin ; MD ; MPH ; ^{maryann.mclaughlin@mssm.edu}
• 刊名：Endocrinology and Metabolism Clinics of North America
• 出版年：2007
• 出版时间：June 2007
• 年：2007
• 卷：36
• 期：2
• 页码：365-377
• 全文大小：186 K

文摘

Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.