ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle
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- 作者：Simone Calderanoa ; c ; Patricia Godoya ; Daiane Soaresa ; c ; Osvaldo Augusto Sant&rsquo ; Annab ; c ; Sergio Schenkmand ; M. Carolina Eliasa ; c ; carolina.eliassabbaga@butantan.gov.br" class="auth_mail
- 关键词：DNA replication ; ORC1/CDC6 ; MCM7 ; Trypanosoma cruzi
- 刊名：Molecular and Biochemical Parasitology
- 出版年：February 2014
- 年：2014
- 卷：193
- 期：2
- 页码：110-113
- 全文大小：910 K
文摘
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The component of pre-replication complex TcORC1/CDC6 does not bind DNA in non-replicative stages of Trypanosoma cruzi life cycle.
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The other component of the pre-replication complex TcMCM7 is not expressed in non-replicative stages of the T. cruzi life cycle.
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We provide possible molecular basis for the lack of DNA replication in non-proliferative stages.