Patients With Heart Failure Have an?Increased?Risk of Incident Cancer

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• 作者：Tal Hasin ; Yariv Gerber ; Sheila M. McNallan ; Susan A. Weston ; Sudhir S. Kushwaha ; Timothy J. Nelson ; James R. Cerhan ; Veronique L. Roger
• 关键词：cancer ; epidemiology ; follow-up studies ; heart failure ; risk
• 刊名：Journal of the American College of Cardiology
• 出版年：2013
• 出版时间：3 September, 2013
• 年：2013
• 卷：62
• 期：10
• 页码：881-886
• 全文大小：370 K

文摘

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Objectives

This study sought to evaluate the risk of cancer in patients with heart failure (HF) compared with community controls and to determine the impact of cancer post-HF on outcomes.

Background

HF is associated with excess morbidity and mortality. Noncardiac causes of adverse outcomes in HF are increasingly recognized, but not fully characterized.

Methods

In a case-control study, we compared the history of cancer among community subjects newly diagnosed with HF from 1979 to 2002 to age-, sex-, and date-matched community controls without HF (961 pairs). Individuals without cancer at the index date (596 pairs) were followed for cancer in a cohort design, and the survival of HF patients who developed cancer was assessed.

Results

Before the index date, 22 % of HF cases and 23 % of controls had a history of cancer (odds ratio [OR]: 0.94; 95 % confidence interval [CI]: 0.75 to 1.17). During 9,203 person-years of follow-up (7.7 ¡À 6.4 years), 244 new cancer cases were identified; HF patients had a 68 % higher risk of developing cancer (hazard ratio [HR]: 1.68; 95 % CI: 1.13?to 2.50) adjusted for body mass index, smoking, and comorbidities. The HRs were similar for men and women, with a trend toward a stronger association among subjects?¡Ü75 years of age (p?= 0.22) and during the most recent time period (p?= 0.075). Among HF cases, incident cancer increased the risk of death (HR: 1.56; 95 % CI: 1.22 to 1.99) adjusted for age, sex, index year, and comorbidities.

Conclusions

HF patients are at increased risk of cancer, which appears to have increased over time. Cancer increases mortality in HF, underscoring the importance of noncardiac morbidity and of cancer surveillance in the management of HF patients.