Emerging differential roles of the pRb tumor suppressor in trichodysplasia spinulosa-associated polyomavirus and Merkel cell polyomavirus pathogeneses
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- 作者：Julie H. Wua ; b ; Rebecca A. Simonettea ; Harrison P. Nguyena ; b ; Hung Q. Doana ; Peter L. Radya ; Stephen K. Tyringa ; styring@ccstexas.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TSPyV ; trichodysplasia spinulosa-associated polyomavirus ; TS ; trichodysplasia spinulosa ; MCPyV ; Merkel cell polyomavirus ; MCC ; Merkel cell carcinoma ; sT antigen ; small T antigen ; LT antigen ; large T antigen ; pRb ; retinoblastoma protein ; PP2A ; protein phosphatase 2A ; MEK ; mitogen/extracellular signal-regulated kinases ; ERK ; extracellular signal-regulated kinases
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：40-43
- 全文大小：455 K
文摘
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MCPyV and TSPyV encode small tumor (sT) antigens, which differentially regulate cell proliferation pathways.
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Cellular expression of TSPyV sT markedly enhanced pRb phosphorylation and inactivation.
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In contrast, MCPyV sT did not alter pRb phosphorylation status.
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TSPyV-mediated pRb deactivation may play an important role in TS development.