High load of Merkel cell polyomavirus DNA detected in the normal skin of Japanese patients with Merkel cell carcinoma
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- 作者：Yumiko Hashidaa ; Kimiko Nakajimab ; Hideki Nakajimab ; Takeo Shigab ; Moe Tanakaa ; Masanao Murakamia ; Shigenobu Matsuzakia ; Seiji Naganumac ; Naoki Kurodad ; Yasutaka Sekie ; Harutaka Katanof ; Shigetoshi Sanob ; Masanori Daibataa ; daibatam@kochi-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Merkel cell polyomavirus ; Merkel cell carcinoma ; Human skin virome ; MCPyV genotype
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：82
- 期：Complete
- 页码：101-107
- 全文大小：1262 K
文摘
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High levels of MCPyV DNA were found in the normal skin of patients with MCC.
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The levels were significantly higher than in healthy skins of a control cohort.
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The MCPyV genotypes differed between isolates from MCC tumors and from normal skin.
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MCC can occur with a background of high MCPyV load in the skin.
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A patient with MCC carrying a very high load of MCPyV in normal skin is described.