Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4
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- 作者：Po-Lin Lina ; Jinghua Tsai Changa ; De-Wei Wuc ; Chi-Chou Huangb ; Huei Leec ; hl@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytoplasmic Nrf2 ; PSMD4 ; Colorectal cancer
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：121-132
- 全文大小：7286 K
文摘
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An increase in PSMD4 by cNrf2 promotes cell invasion.
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An increase in PSMD4 by cNrf2 reciprocally promotes Nrf2 nuclear export.
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The increase in HIF-1α and nuclear β-catenin by cNrf2 up-regulates PSMD4 expression at the transcriptional level.
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Metastatic tumors in nude mice induced by the cNrf2 can be completely suppressed by carfilzomib.
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CNrf2 may predict poor outcome in colorectal cancer. Carfilzomib might improve tumor regression and outcomes in patients who harbor cNrf2 tumors.