Antibiotic tigecycline enhances cisplatin activity against human hepatocellular carcinoma through inducing mitochondrial dysfunction and oxidative damage

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• 作者：Jun Tan^a ; Meijun Song^b ; Mi Zhou^c ; ^{zmdoctor1@163.com} ; Yaoren Hu^a ; ^{huyaoren@163.com}
• 关键词：HCC ; Tigecycline ; Mitochondrial inhibition ; Oxidative damage ; Chemo-resistance
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：17-23
• 全文大小：1275 K
• 卷排序：483

文摘

Tigecycline selectively targets HCC in vitro and in vivo. Tigecycline enhances HCC cell response to chemotherapeutic drug. Tigecycline inhibits mitochondrial translation and functions in HCC cells. Tigecycline induces oxidative stress and damage in HCC cells. Mitochondrial biogenesis and respiration is higher in HCC than normal liver cells.