Integrin-linked kinase regulates cellular mechanics facilitating the motility in 3D extracellular matrices

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• 作者：Tom Kunschmann ; Stefanie Puder ; Tony Fischer ; Jeremy Perez ; Nils Wilharm ; Claudia Tanja Mierke ; ^{claudia.mierke@uni-leipzig.de} ;
• 关键词：ILK ; integrin linked kinase ; FAK ; focal adhesion kinase ; PP1a ; protein phosphatase 1a
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1864
• 期：3
• 页码：580-593
• 全文大小：2396 K
• 卷排序：1864

文摘

ILK is involved in providing cellular stiffness. ILK-dependent cellular stiffness relies on structural mechanical-coupling. ILK-dependent stiffness is independent of cell adhesion. ILK-dependent invasiveness is facilitated by ILK-evoked cellular stiffness and forces.