Effects of ZD7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on term-pregnant rat uterine contractility in vitro

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• 作者：Mohammed Alotaibi^a ; ^{mfalotaibi@ksu.edu.sa} ; Karima Kahlat^b ; Taoufik Nedjadi^c ; Laiche Djouhri^a
• 关键词：Uterus ; HCN channels ; Contraction ; ZD7288 ; Smooth muscle
• 刊名：Theriogenology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：141-146
• 全文大小：1061 K
• 卷排序：90

文摘

Pregnant uterine contractility is modulated by HCN channels. Blocking HCN channels with ZD7288 decreases or inhibits the uterine activity. The mechanism relies on preventing calcium entry into the myometrial cells.