Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish
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- 作者：Szu-Hung Chu ; Pei-Han Liao ; Pei-Jen Chen ; chenpj@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Triadimenol ; Triadimenfon ; Medaka (Oryzias latipes) ; Cytochrome P450 (CYP) ; Developmental toxicity ; Reproductive toxicity
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：181-189
- 全文大小：1432 K
文摘
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We show reproduction toxicity in medaka with early life exposure to triadimenol.
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Triadimenol causes persistent and transgenerational endocrine disruption in medaka.
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Triadimenol interrupts gene expression for controlling hormone homeostasis and reproduction.
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Conazoles share similar disruption in hormone homeostasis and reproduction in fish and mammals.