TGFβ-2 signaling is essential for osteoblast migration and differentiation during fracture healing in medaka fish
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- 作者：Kazuhiro Takeyamaa ; b ; Masahiro Chatania ; Keiji Inohayaa ; Akira Kudoa ; akudo@bio.titech.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：TGFβ-2 ; Fracture healing ; Osteoblast ; Osteoclast ; Live-imaging ; Medaka
- 刊名：Bone
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：68-78
- 全文大小：2625 K
文摘
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Tgfβ-2 was uniquely expressed in the bone-forming region of medaka fish.
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Type X collagen-positive osteoblasts migrated to the fracture site and differentiated into osterix-positive osteoblasts.
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Fracture healing was carried by osteoblast migration rather than by proliferation.
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Inhibition of TGFβ signaling impaired the migration of osteoblasts and the differentiation of osteoblasts and osteoclasts.