Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish
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- 作者：Tzu-Yi Tua ; Chwan-Yang Honga ; Takao Sasadob ; Shosaku Kashiwadac ; Pei-Jen Chena ; chenpj@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Propiconazole ; Medaka (Oryzias latipes) ; Oxidative stress ; p53 ; Carcinogenesis
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：170
- 期：Complete
- 页码：52-61
- 全文大小：2773 K
文摘
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Propiconazole initiates ROS-induced oxidative stress and damage in medaka fish.
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Early life exposure to propiconazole increases incidence of hepatocarcionogensis in p53−/− medaka.
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Oxidative stress and CYP induction involved in p53 regulation are key events in propiconazole-induced hepatotumorigenesis.
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Propiconazole-induced toxic response in medaka is compatible with that in rodents.