Current and future potential of metallo drugs: Revisiting DNA-binding of metal containing molecules and their diverse mechanism of action
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- 作者：Mehvash ZakiAuthor Vitae ; Farukh ArjmandAuthor Vitae ; Sartaj Tabassum ; tsartaj62@yahoo.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Medicinal inorganic chemistry ; Platinum and non-platinum antitumor drugs ; Cu(II) ; Zn(II) ; Ag(I) ; Au(I) ; Au(II) antitumor complexes ; DNA-binding ; Cytotoxicity
- 刊名：Inorganica Chimica Acta
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：444
- 期：Complete
- 页码：1-22
- 全文大小：6580 K
文摘
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Platinum based anticancer drugs in clinical trials have serious side effects.
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Anticancer drug screening is most attractive field due to increasing cancer threats.
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Metal complexes show mechanism of action different from that of cisplatin.
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Design of agents targeting DNA and mitochondria is important in medicinal chemistry.