α-Tocopheryl linolenate solid lipid nanoparticles for the encapsulation, protection, and release of the omega-3 polyunsaturated fatty acid: in vitro anti-melanoma activity evaluation
文摘
SLNs based on α-tocopheryl linolenate were prepared and characterized. α-tocopheryl linolenate and the obtained SLNs show an excellent antioxidant activity. SLNs deliver and the protect unstable molecules, such as α-linolenic acid, from degradation. SLNs are more effective than both α-linolenic acid α-tocopherol in inhibiting human melanoma cell viability in vitro. SLNs could be good candidates for further in vivo studies to develop potential agents in the treatment of melanoma.