Brucella abortus S19 vaccine protects dairy cattle against natural infection with Brucella melitensis

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• 作者：Michael van Straten^a ; ^{vanstraten@hachaklait.co.il" class="auth_mail" title="E-mail the corresponding author} ; Svetlana Bardenstein^b ; Gaby Keningswald^a ; Menachem Banai^b
• 关键词：Brucella abortus ; Brucella melitensis ; Cattle ; Cross protection ; Vaccines
• 刊名：Vaccine
• 出版年：2016
• 出版时间：21 November 2016
• 年：2016
• 卷：34
• 期：48
• 页码：5837-5839
• 全文大小：306 K

文摘

Brucellosis is a zoonotic disease that can cause severe illness in humans and considerable economic loss in the livestock industry. Although small ruminants are the preferential host for Brucella melitensis, this pathogen has emerged as a cause for Brucella outbreaks in cattle. S19 vaccination is implemented in many countries where B. abortus is endemic but its effectiveness against B. melitensis has not been validated. Here we show that vaccine effectiveness in preventing disease transmission between vaccinated and unvaccinated cohorts, as determined by seroconversion, was 87.2% (95% CI 69.5–94.6%). Furthermore, vaccination was associated with a reduced risk for abortion. Together, our data emphasize the role S19 vaccination could play in preventing B. melitensis outbreaks in areas where this pathogen is prevalent in small ruminant populations.