Comparison of potential protection conferred by three immunization strategies (protein/protein, DNA/DNA, and DNA/protein) against Brucella infection using Omp2b in BALB/c Mice

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• 作者：Maryam Golshani^a ; Sima Rafati^b ; Mehdi Nejati-Moheimani^c ; Melina Ghasemian^a ; Saeid Bouzari^a ; ^{saeidbouzari@yahoo.com} ; ^{bouzari@pasteur.ac.ir}
• 关键词：Brucella melitensis ; Brucella abortus ; Omp2b ; Recombinant protein ; DNA vaccine ; Prime-boost strategy ; Cross protection
• 刊名：Veterinary Microbiology
• 出版年：2016
• 出版时间：25 December 2016
• 年：2016
• 卷：197
• 期：Complete
• 页码：47-52
• 全文大小：896 K
• 卷排序：197

文摘

The immunogenicity and protective efficiency of the Omp2b were evaluated against Brucella infection. Omp2b immunization induces a vigorous humoral response. Omp2b DNA priming protein boosting immunization induces higher levels of Th1 responses comparing to DNA or protein alone. Omp2b DNA priming protein boosting immunizations induces protection levels compatible to RB51 and REV-1 vaccines against B. melitensis and B. abortus challenge. Omp2b could be a potential candidate for the development of new subunit vaccines against B. melitensis and B. abortus infection.