DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan
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- 作者：Ji Caoa ; Guanyu Lina ; Yanling Gonga ; Peichen Panb ; Yaxi Mad ; Ping Huange ; Meidan Yinga ; Tingjun Houb ; c ; Qiaojun Hea ; Bo Yanga ; yang924@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acriflavine ; Target identification ; DNA-PKcs ; Melphalan ; p53
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：115-124
- 全文大小：3377 K
文摘
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Acriflavine directly binds to DNA-PKcs and inhibits its kinase activity particularly.
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Acriflavine enhances the DNA damage caused by melphalan and exerts synergistic efficacy with melphalan against cancer cells.
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The p53 status dictated the cell fate in response to the combination therapy.