Simultaneous determination of amantadine, rimantadine, and memantine in processed products, chicken tissues, and eggs by liquid chromatography with tandem mass spectrometry
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- 作者：Yumi Tsuruoka ; Yumi_Tsuruoka@member.metro.tokyo.jp ; Takayuki Nakajima ; Maki Kanda ; Hiroshi Hayashi ; Yoko Matsushima ; Souichi Yoshikawa ; Marie Nagata ; Hiroshi Koike ; Chieko Nagano ; Kotaro Sekimura ; Tsuneo Hashimoto ; Ichiro Takano ; Tetsuya Shindo
- 关键词：Amantadine ; Rimantadine ; Memantine ; LC&ndash ; MS/MS ; External solvent calibration curve ; Processed products
- 刊名：Journal of Chromatography B
- 出版年：2017
- 出版时间：15 February 2017
- 年：2017
- 卷：1044-1045
- 期：Complete
- 页码：142-148
- 全文大小：1168 K
- 卷排序：1044
文摘
The new validated LC–MS/MS method allows for simultaneous determination of amantadine, rimantadine, and memantine in four processed products, three chicken tissues, and eggs. On a modern Kinetex® XB-C18 core–shell technology column using a mobile phase of acetonitrile and 0.1% formic acid in 10 mmol/L ammonium formate solution, three adamantane drugs could be completely separated. This procedure had a good efficiency by modifying the process of QuEChERS extraction and using a two-step clean-up procedure: liquid-liquid distribution and Oasis® MCX cartridge purification. The external solvent calibration curves were able to accurately quantify three analytes because matrix effects were made negligible by removing matrices in the samples.