The spectrum of oculocutaneous disease: Part II. Neoplastic and drug-related causes of oculocutaneous disease

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• 作者：Antoinette Day ; BS^a ; Amanda K. Abramson ; MD^b ; Mahir Patel ; MD^b ; Richard B. Warren ; MD ; PhD^c ; M. Alan Menter ; MD^b ; ^{amderm@gmail.com" class="auth_mail}
• 关键词：basal cell nevus syndrome ; cutaneous T-cell lymphoma ; drug reactions ; EGFR ; inhibitormultiple myeloma ; oculocutaneous ; periocular neoplasm ; PHACES ; Stevens-Johnson Syndrome ; Sturge Weber Syndrome ; toxic epidermal necrolysis ; xeroderma pigmentosum
• 刊名：Journal of the American Academy of Dermatology
• 出版年：May, 2014
• 年：2014
• 卷：70
• 期：5
• 页码：821.e1-821.e19
• 全文大小：634 K

文摘

There are a multitude of diseases that commonly affect both the skin and the eye. Part II of this 2-part series reviews the oculocutaneous manifestations of neoplasms, both benign and malignant, and adverse drug reactions affecting the skin and the eye. Though rare, a number of neoplasms that primarily involve the skin, such as melanoma and basal cell carcinoma, can metastasize to the eye, leading to permanent damage if not properly treated. In addition, periocular neoplasms can irritate the conjunctiva and lid, reducing a patient's ability to see clearly. Neoplastic diseases, such as xeroderma pigmentosum, Sturge-Weber syndrome, and multiple myeloma, can also lead to permanent changes in the eye if not discovered and managed promptly. Furthermore, there are a multitude of drugs, including those commonly used by dermatologists, which can result in permanent damage to the eye. With proper knowledge of the ocular manifestations and treatment recommendations described in this 2-part series, dermatologists with the assistance of their ophthalmology colleagues can help avoid the complications, including permanent blindness, associated with infectious, inflammatory, genetic, neoplastic, and drug-related conditions.