The mesenchymal transcription factor SNAI-1 instructs human liver specification
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- 作者：Orit Goldman ; Victor Julian Valdes ; Elena Ezhkova ; Valerie Gouon-Evans ; valerie.gouon-evans@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hESC ; human embryonic stem cell ; Hep cells ; hESC-derived hepatic cells ; FACS ; fluorescence-activated cell sorting ; PDGFRα ; platelet-derived growth factor receptor alpha ; KDR (VEGFR2 or FLK-1) ; kinase insert domain receptor ; SNAI-1 ; Snail-1 ; SNAI-2 ; Snail-2 ; EMT ; epithelial-mesenchymal transition ; MET ; mesenchymal-epithelial transition ; AFP ; alpha fetoprotein ; ALB ; albumin ; EpCAM ; epithelial cell adhesion molecule ; CDH1 ; E-cadherin
- 刊名：Stem Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：17
- 期：1
- 页码：62-68
- 全文大小：1461 K
文摘
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hESC-derived hepatic cells express both mesenchymal and epithelial markers.
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SNAI-1 controls cell autonomously hepatic specification of hESC-derived Hep cells.