The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D2 receptor occupancy and stimulus generalization to a d-amphetamine cue
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- 作者：Peter H. Hutsona ; phutson@shire.com" class="auth_mail" title="E-mail the corresponding author ; Helen L. Rowleyb ; James Gosdenb ; Rajiv S. Kulkarnib ; Nigel Slaterb ; Patrick L. Lovec ; Yiyun Wangc ; David Healb
- 关键词：Lisdexamfetamine ; Prefrontal cortex ; Nucleus accumbens ; Dopamine efflux ; Dopamine D2 receptor occupancy ; Drug discrimination
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：101
- 期：Complete
- 页码：24-35
- 全文大小：1139 K
文摘
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Lisdexamfetamine and olanzapine increased dopamine efflux in cortex and accumbens more than either drug individually.
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Lisdexamfetamine did not affect olanzapine's ability to block striatal D2 receptors.
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The ability of lisdexamfetamine to generalize to a d-amphetamine cue was attenuated by olanzapine.