Chronic nicotine and withdrawal affect glutamatergic but not nicotinic receptor expression in the mesocorticolimbic pathway in a region-specific manner
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- 作者：Francesco Pistilloa ; Francesca Fasolia ; 1 ; Milena Morettia ; Tristan McClure-Begleyb ; Michele Zolic ; Michael J. Marksb ; d ; marksm@colorado.edu" class="auth_mail" title="E-mail the corresponding author ; Cecilia Gottia ; c.gotti@in.cnr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chronic nicotine ; Nicotine withdrawal ; Nicotinic acetylcholine receptors ; Metabotropic glutamate receptors ; NMDA and AMPA glutamate receptors
- 刊名：Pharmacological Research
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：103
- 期：Complete
- 页码：167-176
- 全文大小：1817 K
文摘
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Chronic nicotine up-regulates heteromeric β2-containing nicotinic receptors in the mesocorticolimbic pathway.
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These receptors are rapidly removed from mesocorticolimbic synapses upon nicotine cessation.
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Glutamate receptor expression in this pathway is regulated in a region-specific manner during nicotine exposure and withdrawal.