Activation of CRHR1 receptors regulates social and depressive-like behaviors and expression of BDNF and TrkB in mesocorticolimbic regions following global cerebral ischemia
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- 作者：Patricia Barra de la Tremblayea ; pbarr066@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Nicolas Narvaez Linaresa ; nnarv038@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Sarah Schockb ; smcke044@uottawa.ca" class="auth_mail" title="E-mail the corresponding author ; Hé ; lè ; ne Plamondona ; hplamond@uottawa.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Global cerebral ischemia ; CRHR1 ; Depressive-like behavior ; Social interaction ; Brain plasticity ; Corticosterone
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：284
- 期：part_PA
- 页码：84-97
- 全文大小：2498 K
文摘
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Global ischemia increases despair and anhedonia, and affects behavioral impulsivity.
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Global ischemia reduces vs increases BDNF/TrkB expression at the mPFC and NAc.
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CRHR1 blockade prevents/inhibits ischemic impaired emotionality and brain plasticity.